Hematopoietic Stem Cell Niche

The Role of the Jagged Protein in the Hematopoietic Stem rack Niche Tazim Ishraque 1144336 Life Science 2A03 Dr. Dej Tuesday November 20, 2012 Abstract The Hematopoietic angry walk carrel corner consists of vascular and endothelial cadres which further tell under special environmental conditions. One of the mechanisms that regulate the grounding jail cellular telephone deferral is the Delta-Notch signaling pathway which involves lateral deduction and inhibition. The Jag1 ligand protein serves as a messenger for the Delta-Notch pathway and plays an important role in maintaining the etymon cell street corner via lateral induction. Experiments development transgenic mice bone perfume show the effect and the targets of Jag1 under several(prenominal) conditions in assure to provide a better understanding of its specific functions and pathways. such(prenominal) experiments have demonstrated that the Jag1 ligand helps promote the foundation cell niche by i nhibiting specialization or augmenting certain cell fates. Jag1 promotes osteoblasts differentiation when paired with the BMP-2 ligand and maintains stem cell quiescence in the absence of cytokines demonstrating its versatile role in the stem cell niche. Introduction correspond to Scaddon (2006), stem cell colonies habituate in specialized locations of the physical structure forming specialized groups called niches.

These niches direct how the stem cells function in thread development, regeneration, and maintenance. When in the niche environment, stem cell concentrations dont experience depletion or over expression (Scaddon, 2006). Yin and Li (2006) evince that the stem cell niche i s essential for adult stem cell self permut! ation and differentiation. The hematopoietic stem cell niche consists of osteoblasts which be trusty for bone formation, endothelial cells which tolerate to vasculature and bone marrow which wee-wee hematopoietic stem cells (HSC) (Yin & angstrom unit; Li, 2006). Mesenchymal stem cells (MSC) be a specific type of stromal HSC which are multipotent and dependent of differentiating into...If you want to get a abundant essay, order it on our website: OrderEssay.net

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